How often should I change the IV administration set?
Some evidence indicates that administration sets that do not contain lipids, blood or blood products may be left in place for intervals of up to 96 hours without increasing the risk of infection. Other evidence suggests that mortality increased within the neonatal population with infrequent administration set replacement. However, much of the evidence obtained was derived from studies of low to moderate quality.
Ullman AJ, Cooke ML, Gillies D, Marsh NM, Daud A, McGrail MR, et al. Optimal timing for intravascular administration set replacement. Cochrane Database Syst Rev. 2013;9:Cd003588. http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD003588.pub3/abstract